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- Title
False-positive Troponin I Assay elevation due to occult Mixed Cryoglobulinemic Vasculitis.
- Authors
Odish, Mazen; Beben, Tomasz; Daniels, Lori B.
- Abstract
A 53-year-old man with active hepatitis C and cirrhosis presented with a vasculitic rash, myalgias, and fatigue, and was found to have an elevated cardiac troponin I up to 15.7 ng/mL with normal electrocardiogram, echocardiogram, and coronary angiogram prior to being discharged. Subsequently, during a similar presentation to another academically affiliated hospital, the patient had a normal cardiac troponin T (< 0.01 ng/mL). Upon his third presentation with significantly elevated troponin I to 15.98 ng/mL, the patient was found to have cryoglobulinemic vasculitis and elevated rheumatoid factor due to active hepatitis C, causing interference with the troponin I immunoassay. In conclusion, troponin I assays may have high false-positive values due to interference by rheumatoid factor and/or a polyclonal antibody found in cryoglobulinemia.
- Publication
Reviews in Cardiovascular Medicine, 2018, Vol 19, Issue 2, p73
- ISSN
1530-6550
- Publication type
journal article
- DOI
10.31083/j.rcm.2018.02.902