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- Title
Učestalost haplotipskih sveza HLA-DRB1-DQA1-DQB1 u psorijatičara s pozitivnom i negativnom obiteljskom anamnezom psorijaze.
- Authors
Kaštelan, Marija; Massari, Larisa Prpić; Brajac, Ines; Peternel, Sandra; Jeličić, Esma Čečuk; Grubić, Zorana; Kaštelan, Andrija
- Abstract
Aim: To analyze the distribution of HLA-DRB1-DQA1-DQB1 haplotypes as well as the extended haplotype Cw*0602-B57-DRB1*07-DQA1*0201-DQB1*0201 in patients with positive and negative family history of psoriasis. Patients and methods: The association of HLA genes classes I and II with psoriasis has been studied in 118 patients with chronic stable psoriasis. The frequency of HLA haplotypes was analyzed by means of serology and hybridization with specific oligonucleotide probes. Results: The group with positive family history showed a significant association with DRB1*07-DQA1*0201-DQB1*0201 and DRB1*07-DQA1*0201-DQB1*0303 as well as with the extended haplotype Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0201 (P = 0,004). The frequency of extended haplotype in the group with negative family history was similar to the control group. Conclusion: Psoriatics with positive family history show stronger association with susceptible HLA haplotypes, thus stressing the role of HLA genes in psoriasis inheritance.
- Publication
Medicina Fluminensis, 2015, Vol 51, Issue 2, p283
- ISSN
1847-6864
- Publication type
Article