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- Title
PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma.
- Authors
Fen Liu; Yan He; Yong Liang; Lijun Wen; Yongming Zhu; Yan Wu; Lixiang Zhao; Yunsen Li; Xinliang Mao; Haiyan Liu
- Abstract
Background Lup-20(29)-en-3H-ol (Lupeol), a dietary triterpene, has been shown to possess multiple pharmacological activities including anti-tumor effects Methods In the current study, we noted that low doses of lupeol (<40µM) promoted the growth of hepatocellular carcinoma (HCC) cells with a significant activation of the PI3-kinase/Akt signaling pathway. We further investigated the combined anti-tumor effect of lupeol and S14161, a newly identified PI3-Kinase inhibitor in vitro and in vivo Results The results demonstrated that lupeol and S14161 could exert a synergistic antitumor effect resulting in chemo-sensitization of HCC to low doses of lupeol. Using an in vivo HCC model, we further demonstrated that lupeol and S14161 synergistically inhibited tumor growth without any adverse effects on body weight Conclusion Our studies showed that the activation of PI3-kinase/Akt pathway resulted in the tumorpromoting effect with low doses of lupeol. Combining PI3-kinase inhibitor with lupeol could synergistically augment the anti-tumor effect of lupeol and might be an applicable strategy for HCC therapy.
- Subjects
LIVER cancer; TRITERPENES; KINASE inhibitors; TRANSFORMING growth factors; TUMOR growth
- Publication
Cancer Cell International, 2013, Vol 13, Issue 1, p1
- ISSN
1475-2867
- Publication type
Article
- DOI
10.1186/1475-2867-13-108