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- Title
MONTE CARLO DOSIMETRY FOR TARGETED IRRADIATION OF INDIVIDUAL CELLS USING A MICROBEAM FACILITY.
- Authors
lncerti, S.; Seznec, H.; Simon, M.; Barberet, Ph.; Habchi, C.; Moretto, Ph.
- Abstract
Microbeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the delivered dose. This paper describes dosimetry calculations performed at the single-cell level in the microbeam irradiation facility available at the Centre d'Etudes Nucléaires de Bordeaux-Cradignan in France, using (he object-oriented Geant4 Monte Carlo simulation toolkit. The cell geometry model is based on high-resolution three-dimensional voxelised phantoms of a human keratinocyte (HaCaT) cell line. Such phantoms are built from confocal microscopy imaging and from ion beam chemical elemental analysis. Results are presented for single-cell irradiation with 3 MeV incident alpha particles.
- Subjects
FRANCE; EFFECT of radiation on cells; IONIZING radiation; KERATINOCYTES; ALPHA rays; CONFOCAL microscopy; RADIATION dosimetry; MONTE Carlo method
- Publication
Radiation Protection Dosimetry, 2009, Vol 133, Issue 1, p2
- ISSN
0144-8420
- Publication type
Article
- DOI
10.1093/rpd/ncp003