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- Title
AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus
- Authors
Coope, Andressa; Milanski, Marciane; Araújo, Eliana P.; Tambascia, Marcos; Saad, Mário J.A.; Geloneze, Bruno; Velloso, Lício A.
- Abstract
Abstract: Adiponectin exerts an insulin-sensitizing effect, improving insulin action in peripheral tissues and restraining insulin resistance. Here, we explore the hypothesis that adiponectin can reproduce some of the actions of insulin/leptin in the hypothalamus. The presence of AdipoR1 and AdipoR2 was mapped to the arcuate and lateral hypothalamic nuclei. Icv adiponectin reduced food intake, which was accompanied by activation/engagement of IRS1/2, ERK, Akt, FOXO1, JAK2 and STAT3. All these actions were dependent on AdipoR1, since inhibition of this receptor, and not of AdipoR2, completely reversed the effects described above. Thus, adiponectin acts in the hypothalamus, activating elements of the canonical insulin and leptin signaling pathways and promoting reduction of food intake.
- Subjects
INSULIN; LEPTIN; HYPOTHALAMUS; INGESTION
- Publication
FEBS Letters, 2008, Vol 582, Issue 10, p1471
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.03.037