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- Title
Oleic acid: An efficient inhibitor of glucosyltransferase
- Authors
Won, Se-Ra; Hong, Mi-Jung; Kim, Yong-Mu; Li, Chun Ying; Kim, Jang-Won; Rhee, Hae-Ik
- Abstract
Abstract: Among the extracts from 420 kinds of herbs, Prunus salicina, showing the highest glucosyltransferase inhibition activity, was purified and designated GTI-0163. Structural determination of GTI-0163 revealed it to be an oleic acid-based unsaturated fatty acid. GTI-0163 was an uncompetitive inhibitor of GTase. Among the unsaturated fatty acids, oleic acid showed a significantly higher GTase inhibitory activity than the saturated fatty acids or the ester form of oleic acid. These results strongly suggested that both the number of double bonds and the existence of free carboxyl groups of fatty acids play an important role in GTase inhibitory activity.
- Subjects
OLEIC acid; GLYCOSYLTRANSFERASES; CHEMICAL inhibitors; FATTY acids
- Publication
FEBS Letters, 2007, Vol 581, Issue 25, p4999
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.09.045