We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha
- Authors
Ishimoto, Kenji; Tachibana, Keisuke; Sumitomo, Mikako; Omote, Shiho; Hanano, Ikuko; Yamasaki, Daisuke; Watanabe, Yuichiro; Tanaka, Toshiya; Hamakubo, Takao; Sakai, Juro; Kodama, Tatsuhiko; Doi, Takefumi
- Abstract
Abstract: Liver X receptor alpha (LXRα) is a member of the nuclear receptor superfamily that is activated by oxysterols, and plays a pivotal role in regulating the metabolism, transport and uptake of cholesterol. Here, we demonstrate that LXRα also regulates the low-density lipoprotein receptor (LDLR) gene, which mediates the endocytic uptake of LDL cholesterol in the liver. An LXR agonist induced the expression of LDLR in cultured hepatoblastoma cells. Moreover, the LDLR promoter contained an LXR response element that was recognized by LXRα/RXRα (retinoid X receptor alpha) heterodimers in hepatoblastoma cells. These results suggest a novel pathway whereby LXRα might modulate cholesterol metabolism.
- Subjects
ISOPENTENOIDS; CHOLESTEROL; CARRIER proteins; PROTEIN binding
- Publication
FEBS Letters, 2006, Vol 580, Issue 20, p4929
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.08.010