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- Title
A novel radiolabeled indole derivative as solid tumor imaging agent: in silico and preclinical pharmacological study.
- Authors
Shamsel-Din, H.; Ibrahim, A.
- Abstract
Biologically active indole derivative was synthesized and screened for its cytotoxicity against breast cancer cell line (MCF-7) with the IC equals 17.5 µg/mL. Docking study showed its high binding affinity to the COX-2 enzyme. It's radiolabeling with Tc and showed high radiochemical yield (92.10 ± 0.57%) and in vitro stability in serum up to 10 h. Biodistribution studies of a novel Tc-NSIC complex in tumor-bearing mice showed high T/NT ratio (6.17 ± 0.08 at 30 min. post-injection), suggesting this complex could be used as a solid tumor imaging agent.
- Subjects
INDOLE compounds; ALUMINUM phthalocyanine; CELL-mediated cytotoxicity; CELL lines; CANCER cells
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2017, Vol 314, Issue 3, p2263
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-017-5551-0