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- Title
Total Synthesis and Prediction of Ulodione Natural Products Guided by DFT Calculations**.
- Authors
Bestwick, Jacob S.; Jones, David J.; Jones, Helen E.; Kalomenopoulos, Panagiotis G.; Szabla, Rafal; Lawrence, Andrew L.
- Abstract
A biomimetic synthetic strategy has resulted in a two‐step total synthesis of (±)‐ulodione A and the prediction of two potential natural products, (±)‐ulodiones C and D. This work was guided by computational investigations into the selectivity of a proposed biosynthetic Diels–Alder dimerization, which was then utilized in the chemical synthesis. This work highlights how biosynthetic considerations can both guide the design of efficient synthetic strategies and lead to the anticipation of new natural products.
- Subjects
NATURAL products; BIOMIMETIC materials; CHEMICAL synthesis; BIOMIMETIC synthesis; NEW product development; DIMERIZATION
- Publication
Angewandte Chemie, 2022, Vol 134, Issue 32, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202207004