We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Polymorphism of vascular endothelial growth factor −1154G>A (rs1570360) with cancer risk: a meta-analysis of 16 case-control studies.
- Authors
Hong, Ting-Ting; Zhang, Ru-Xia; Wu, Xiao-Hong; Hua, Dong
- Abstract
Published data on the association of vascular endothelial growth factor (VEGF) −1154G>A polymorphism with cancer risk is inconclusive. To derive a more precise estimation of association between VEGF −1154G>A polymorphism and the risk of cancer, we performed a meta-analysis of 7,071 cancer cases and 7,693 controls from 16 published case-control studies. Our meta-analysis didn't reveal an association between VEGF −1154G>A polymorphism and overall cancer risk (GG vs. AA: OR: 1.08, 95% CI: 0.96-1.20; GA vs. AA: OR: 1.04, 95% CI: 0.93-1.17; recessive model: GG+GA vs. AA: OR: 1.06, 95% CI: 0.95-1.18; dominant model: GG vs. GA+AA, OR: 1.11, 95% CI: 1.00-1.24). Nevertheless, for non-Caucasians, GG homozygote may have higher cancer risk compared with either A carriers (OR: 1.58, 95% CI: 1.12-2.23) or AA homozygote (OR: 1.43, 95% CI: 1.17-1.76). No significant heterogeneity was detected except in the dominant model and 'prostate cancer' subgroup analysis. More studies with larger samples are warranted to confirm these findings.
- Subjects
GENETIC polymorphism research; CANCER genetics; CANCER risk factors research; VASCULAR endothelial growth factors; MOLECULAR biology
- Publication
Molecular Biology Reports, 2012, Vol 39, Issue 5, p5283
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-011-1326-9