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- Title
Upregulation of interleukin-1β production by 1,25-Dihydroxyvitamin D in activated human macrophages.
- Authors
Bit-Na-Ra Lee; Tae-Hwan Kim; Jae-Bum Jun; Dae-Hyun Yoo; Jin-Hyun Woo; Sung Jae Choi; Young Ho Lee; Gwan Gyu Song; Yongjin Kim; Ji Young Lee; Jeongwon Sohn; Jong Dae Ji
- Abstract
1,25-Dihydroxyvitamin D (1,25(OH)D) plays important roles in the immune system. In contrast to its well known function in the adaptive immune system, much less is known about the immunoregulatory effects of 1,25(OH)D in the innate immune system, especially on activated human macrophages. Here we found that 1,25(OH)D strongly stimulated the production of interleukin-1β (IL-1β) in PMA-differentiated U937 cells and human monocyte-derived macrophages treated with lipopolysaccharide (LPS) or PMA. In this study, Erk1/2 appeared to mediate 1,25(OH)D-induced expression of IL-1β. Parallel to the increased production of IL-1β, 1,25(OH)D increased the expression and phosphorylation of the CCAAT enhancer-binding protein β (C/EBPβ), which is one of the key transcriptional regulatory factors for IL-1β transcription. These results suggest that 1,25(OH)D may function as a proinflammatory molecule in inflammatory macrophages.
- Subjects
INTERLEUKIN-1; IMMUNE system; MACROPHAGES; CHEMICAL reactions; CHOLECALCIFEROL
- Publication
Molecular Biology Reports, 2011, Vol 38, Issue 3, p2193
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-010-0348-z