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- Title
The association between urinary liver-type fatty acid-binding protein and chronic kidney disease classification in HIV-infected Japanese patients.
- Authors
Hikasa, Shinichi; Yasuda, Megumi; Hideta, Kyoko; Kawakami, Mai; Higasa, Satoshi; Sawada, Akihiro; Tokugawa, Tazuko; Kimura, Takeshi
- Abstract
Background: Renal dysfunction is recognized with increasing frequency among the noninfectious comorbidities associated with human immunodeficiency virus (HIV) infection. Urinary liver-type fatty acid-binding protein (L-FABP) has been shown to be a new biomarker to screen for not only tubulointerstitial damage but also kidney dysfunction. Methods: We performed a cross-sectional study to determine the association between the urinary L-FABP and chronic kidney disease (CKD) among 77 HIV-infected Japanese patients by backward-stepwise multivariable logistic regression. Results: The prevalence of individuals in the low risk was 80 %. Urinary L-FABP level was not associated with antiretroviral therapy and tenofovir disoproxil fumarate. On the other hand, urinary L-FABP level was independently associated with the CKD classification. Conclusion: Urinary L-FABP may be used as an adjunct to diagnose the CKD stage.
- Subjects
HIV infection genetics; KIDNEY diseases; FATTY acids; CARRIER proteins; COMORBIDITY
- Publication
Clinical & Experimental Nephrology, 2017, Vol 21, Issue 6, p971
- ISSN
1342-1751
- Publication type
Article
- DOI
10.1007/s10157-016-1347-8