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- Title
Gastric cancers with microsatellite instability exhibit high fluorodeoxyglucose uptake on positron emission tomography.
- Authors
Chung, Hyun; Lee, Sun-Young; Han, Hye; Park, Hyun; Yang, Jae; Lee, Hak; So, Young
- Abstract
Background: Gastric cancers exhibit various degrees of F-fluorodeoxyglucose (FDG) uptakes on positron emission tomography/computed tomography (PET/CT) imaging. The aim of this study was to evaluate whether FDG uptake in gastric cancer varies according to the microsatellite instability (MSI) status. Methods: Consecutive gastric cancer patients who underwent PET/CT imaging and MSI analysis were included in the study. The maximum standardized uptake value (SUV) of gastric cancer was assessed using PET/CT imaging. Results: Of 131 gastric cancers, 16 exhibited a high incidence of MSI (MSI-H) and 3 exhibited a low incidence of MSI (MSI-L). In 29 subjects who showed no uptake on PET/CT imaging the gastric cancers were all microsatellite stable (MSS). Gastric cancers with MSI were related to age older than 60 years ( p = 0.002), cancer volume larger than 10 cm ( p = 0.015), and the presence of FDG uptake on PET/CT imaging ( p = 0.001). A higher SUV of gastric cancer was linked to the presence of MSI ( p < 0.001). Conclusion: The presence of MSI is related to FDG uptake in gastric cancer. Care should be taken with MSS gastric cancers, because they show lower SUV on PET/CT imaging than MSI gastric cancers.
- Subjects
GASTRIC mucosa; MICROSATELLITE repeats; POSITRON emission tomography; COMPUTED tomography; CANCER patients; CANCER
- Publication
Gastric Cancer, 2013, Vol 16, Issue 2, p185
- ISSN
1436-3291
- Publication type
Article
- DOI
10.1007/s10120-012-0165-2