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- Title
HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes.
- Authors
Odermarsky, Michal; Pesonen, Erkki; Sorsa, Timo; Lernmark, Åke; Pussinen, Pirkko J.; Liuba, Petru
- Abstract
Aims: This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D). Methods: Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.Results: cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (<italic>p</italic> = 0.04, <italic>r</italic> = − 0.3; <italic>n</italic> = 62) and FMD (<italic>p</italic> = 0.03, <italic>r</italic> = − 0.3; <italic>n</italic> = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (<italic>p</italic> = 0.03, <italic>r</italic> = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (<italic>p</italic> = 0.04, <italic>r</italic> = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.Conclusions: The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D.
- Subjects
TYPE 1 diabetes; INFLAMMATION; CARDIOVASCULAR diseases; ENDOTHELIAL cells; DISEASE progression
- Publication
Acta Diabetologica, 2018, Vol 55, Issue 1, p41
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-017-1063-1