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- Title
Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle.
- Authors
Eduardo Baroni; Diego Díaz; Eduardo Picco; Samanta Waxman; Casilda Rodríguez; Juan Boggio
- Abstract
Abstract Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in ≥ 7 weeks-old cattle to reach a satisfactory dosage regimen (MIC ≥ 32 μg/mL).
- Subjects
AGE factors in pharmacokinetics; AGE of cattle; SULFONAMIDES; INTRAVENOUS injections; PHARMACODYNAMICS
- Publication
Veterinary Research Communications, 2008, Vol 32, Issue 7, p509
- ISSN
0165-7380
- Publication type
Article
- DOI
10.1007/s11259-008-9053-y