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- Title
Arsenic Exposure Accelerates Atherogenesis in Apolipoprotein E[sup-/-] Mice.
- Authors
Simeonova, Petia P.; Hulderman, Tracy; Harki, Dan; Luster, Michael I.
- Abstract
Determines whether arsenic exposure influences the progression of atherosclerotic plaque formation in apolipoprotein-E mice. Effects of arsenic on molecular events relevant to the major pathogenic mechanisms of atherosclerosis in reference to human vascular cell culture systems; Increase in the size of lesions covering the intimal area of the aorta in arsenic-treated apolipoprotein-E mice compared with non-treated transgenic mice; Role of the induction of endothelial inflammatory activity in arsenic-related vascular effects.
- Subjects
ATHEROSCLEROSIS; ARSENIC in the body; APOLIPOPROTEIN E; MICE
- Publication
Environmental Health Perspectives, 2003, Vol 111, Issue 14, p1744
- ISSN
0091-6765
- Publication type
Article
- DOI
10.1289/ehp.6332