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- Title
Validation of contrast-enhanced ultrasound-derived intensity-time gradients in submandibular gland sialolithotomy patients.
- Authors
Siedek, Vanessa; Rytvina, Margarita; Klotz, Laura; Berghaus, Alexander; Clevert, Dirk-André; Strieth, Sebastian
- Abstract
Contrast-enhanced ultrasound (CE-US)-derived intensity-time gradients (ITGs) can be used for noninvasive monitoring of extracorporeal shock wave sialolithotripsy effects in chronic sialolithiasis-related sialadenitis. Aim of this trial was to further validate CE-US as an independent and quantitative diagnostic tool for sialolithotomy efficacy. In this prospective clinical phase II evidence level c study perfusion in patients ( n = 10) with unilateral sialolithiasis of the submandibular gland was quantitatively analyzed by CEUS before and after sialolithotomy comparing with the contralateral disease-free gland. A visual analog scale (VAS) scoring clinical complaints was correlated with CE-US-derived ITGs. Furthermore, ITG ratios reflecting values from the contralateral side and the diseased side were calculated. VAS documented significantly reduced clinical complaints after sialolithotomy indicative of a successful treatment. VAS data significantly correlated with CE-US-derived ITGs. In addition, ITG ratios were significantly increased after sialolithotomy. In conclusion, CE-US-derived ITGs and ITG ratios appear as independent and valid quantitative parameters of sialolithotomy efficacy.
- Subjects
CONTRAST-enhanced ultrasound; SUBMANDIBULAR gland; EXTRACORPOREAL shock wave lithotripsy; VISUAL analog scale; TREATMENT effectiveness; SURGERY
- Publication
European Archives of Oto-Rhino-Laryngology, 2013, Vol 270, Issue 6, p1941
- ISSN
0937-4477
- Publication type
Article
- DOI
10.1007/s00405-012-2278-y