We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of Survival and Retention Rates between Infliximab and Adalimumab for Psoriasis: 10-Year Experience at a Single Tertiary Center.
- Authors
Onsun, Nahide; Güneş, Begüm; Kaya, Gökhan; Güçkan Işık, Bengisu; Yabacı Tak, Ayşegül
- Abstract
Background: Ten-year survival and retention rate data on biologics are extremely limited, and there is a need to evaluate these metrics based on real-world data as well as on the results of clinical studies. Objective: The objective of this study was to assess the long-term survival rates of adalimumab and infliximab in real-life practice. Methods: This study is based on data from the Turkish Psoriasis Registry and the digital records of the Medical School of Bezmialem Vakif University. Baseline data including demographic characteristics, duration of treatment, use of combination treatments, modified regimens, and reasons for treatment termination were extracted. Results: In total, 404 patients (228 on adalimumab and 176 on infliximab) treated between July 1, 2005, and December 31, 2020, were identified. The retention rate was 7.4% for infliximab and 3.5% for adalimumab after 10 years (p = 0.85). Conclusions: The efficacy of infliximab and adalimumab diminishes over time. There were no significant differences in the retention rate between the two drugs, but the survival time was longer for infliximab according to Kaplan-Meier analysis.
- Subjects
SURVIVAL rate; ADALIMUMAB; INFLIXIMAB; TERMINATION of treatment; ELECTRONIC records
- Publication
Dermatology (10188665), 2023, Vol 239, Issue 3, p355
- ISSN
1018-8665
- Publication type
Article
- DOI
10.1159/000529964