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- Title
Multicomponent synthesis of unsymmetrical 5-nitropyridines.
- Authors
Koveza, Vladislav A.; Kulakov, Ivan V.; Shulgau, Zarina T.; Seilkhanov, Tulegen M.
- Abstract
Reaction of 2-nitroacetophenone, furfurol, β-dicarbonyl compounds, and ammonium acetate led to 3-substituted 4-(2-furyl)-5-nitro-6-phenyl-1,4-dihydropyridines, which were oxidized with potassium nitrate in the presence of copper(II) nitrate (10 mol %), leading to the respective 5-nitro-6-phenylpyridines. The performed multicomponent reactions met the general principles of green chemistry. Synthesis of these unsymmetrical 5-nitro-6-phenylpyridines via the formation of 1,4-dihydropyridine intermediates under the conditions of multicomponent reaction significantly shortened the overall reaction time, decreased the number of steps, and improved the yield.
- Subjects
PYRIDINE synthesis; CARBONYL compounds; AMMONIUM acetate; POTASSIUM nitrate; SUSTAINABLE chemistry
- Publication
Chemistry of Heterocyclic Compounds, 2018, Vol 54, Issue 12, p1127
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-019-02403-x