We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Membrane retrieval at neurosecretory axon endings.
- Authors
NORDMANN, J. J.; MORRIS, J. F.
- Abstract
EARLY descriptions of neurohypophysial hormone release by exocytosis1 suggested that, after exocytotic discharge of the content of the neurosecretory granules (NSG), the membrane of the granule was recaptured in the form of electron-lucent microvesicles of diameter ∼ 50 nm. Such microvesicles were also shown to take up the extracellular marker horseradish peroxidase2. Larger vacuoles of a diameter similar to that of NSG have also been shown to take up this marker in stimulated neurohypophyses3,4. Furthermore, reuptake of membrane into organelles of approximately the size of NSG has also been predicted on the basis of studies of NSG-membrane labelling6 and radioactive extracellular tracer uptake4. We have studied membrane retrieval after stimulation of the rat neurohypophysis by stereology6,7 in an attempt to assess the relative contribution of vacuoles and microvesicles to the membrane reuptake process. Depletion of neurosecretory granules was associated with membrane retrieval by vacuoles of similar size. There was no detectable change in the microvesicle population.
- Publication
Nature, 1976, Vol 261, Issue 5562, p723
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/261723a0