We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mechanisms of Cardiovascular Calcification and Experimental Models: Impact of Vitamin K Antagonists.
- Authors
Siracusa, Chiara; Carino, Annarita; Carabetta, Nicole; Manica, Marzia; Sabatino, Jolanda; Cianflone, Eleonora; Leo, Isabella; Strangio, Antonio; Torella, Daniele; De Rosa, Salvatore
- Abstract
Cardiovascular calcification is a multifactorial and complex process involving an array of molecular mechanisms eventually leading to calcium deposition within the arterial walls. This process increases arterial stiffness, decreases elasticity, influences shear stress events and is related to an increased risk of morbidity and mortality associated with cardiovascular disease. In numerous in vivo and in vitro models, warfarin therapy has been shown to cause vascular calcification in the arterial wall. However, the exact mechanisms of calcification formation with warfarin remain largely unknown, although several molecular pathways have been identified. Circulating miRNA have been evaluated as biomarkers for a wide range of cardiovascular diseases, but their exact role in cardiovascular calcification is limited. This review aims to describe the current state-of-the-art research on the impact of warfarin treatment on the development of vascular calcification and to highlight potential molecular targets, including microRNA, within the implicated pathways.
- Subjects
ANTICOAGULANTS; CALCIFICATION; ARTERIAL calcification; CARDIOVASCULAR disease related mortality; ARTERIAL diseases
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 5, p1405
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13051405