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- Title
Nano ZrO<sub>2</sub>: an efficient, recyclable, and inexpensive catalyst for diastereoselective three-component Mannich reactions.
- Authors
Abaee, M. Saeed; Akbarzadeh, Elahe; Shockravi, Abbas; Mojtahedi, Mohammad M.; Khavasi, Hamid Reza
- Abstract
A facile procedure is developed for the three-component Mannich reactions of several heterocyclic, homocyclic, and acyclic ketones by using catalytic quantities of nano ZrO2. As a result, the starting ketones undergo rapid reactions with a variety of aromatic aldehydes and aniline derivatives at room temperature to produce stereoselectively high yields of the corresponding anti β-amino ketones. Interestingly, the catalyst could be recycled for several runs in a row without significant loss of its activity. The structure of the products was assigned based on their spectroscopic data and the anti stereoselectivity was confirmed by X-ray crystallography.
- Subjects
ZIRCONIUM oxide; MANNICH reaction; HETEROCYCLIC compounds; KETONES; ALDEHYDES; CHEMICAL derivatives
- Publication
Canadian Journal of Chemistry, 2014, Vol 92, Issue 7, p659
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2013-0410