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- Title
Reduced Risk of Progression from Non-Severe to Severe COVID-19 in Hospitalized Dialysis Patients by Full COVID-19 Vaccination.
- Authors
Ichii, Mitsuru; Kurajoh, Masafumi; Okute, Yujiro; Ihara, Yasutaka; Imai, Takumi; Morioka, Tomoaki; Mori, Katsuhito; Shoji, Tetsuo; Tsujimoto, Yoshihiro; Ubai, Takanobu; Emoto, Masanori
- Abstract
Coronavirus disease 2019 (COVID-19) vaccination reduces the risk of progression to severe COVID-19 in the general population. To examine that preventive effect in dialysis patients, the association of vaccination status with severe COVID-19 progression was investigated in this retrospective observational study conducted from December 2020 to May 2022 of 100 such patients hospitalized for non-severe COVID-19 at Inoue Hospital (Suita, Japan). Fifty-seven were fully vaccinated, defined as receiving a COVID-19 vaccine second dose at least 14 days prior to the onset of COVID-19, while 43 were not. Among all patients, 13 (13.0%) progressed to severe COVID-19 with a median (interquartile range) time of 6 (2.5–9.5) days, while 87 (87.0%) were discharged after 11 (8–16) days. Kaplan–Meier analysis showed that fully vaccinated patients had a significantly lower rate of progression to severe COVID-19 (p = 0.001, log-rank test). Cox proportional hazard analysis also indicated that full COVID-19 vaccination was significantly associated with reduced instances of progression to severe COVID-19 (hazard ratio 0.104, 95% confidence interval 0.022 to 0.483; p = 0.004) after balancing patient background characteristics using an inverse probability of treatment weight method. These results suggest that full vaccination status contributes to reducing the risk of progression from non-severe to severe COVID-19 in dialysis patients.
- Subjects
COVID-19; COVID-19 vaccines; HEMODIALYSIS patients; HOSPITAL patients; VACCINATION status
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 21, p6348
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11216348