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- Title
The Role of Neuropeptides in Pathogenesis of Dry Dye.
- Authors
Hwang, Daniel Duck-Jin; Lee, Seok-Jae; Kim, Jeong-Hun; Lee, Sang-Mok
- Abstract
Neuropeptides are known as important mediators between the nervous and immune systems. Recently, the role of the corneal nerve in the pathogenesis of various ocular surface diseases, including dry eye disease, has been highlighted. Neuropeptides are thought to be important factors in the pathogenesis of dry eye disease, as suggested by the well-known role between the nervous and immune systems, and several recently published studies have elucidated the previously unknown pathogenic mechanisms involved in the role of the neuropeptides secreted from the corneal nerves in dry eye disease. Here, we reviewed the emerging concept of neurogenic inflammation as one of the pathogenic mechanisms of dry eye disease, the recent results of related studies, and the direction of future research.
- Subjects
EYE diseases; DRY eye syndromes; NEUROPEPTIDES; PATHOGENESIS; NERVOUS system; CALCITONIN gene-related peptide
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 18, p4248
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10184248