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- Title
Role of the Immune System Elements in Pulmonary Arterial Hypertension.
- Authors
Tomaszewski, Michał; Bębnowska, Dominika; Hrynkiewicz, Rafał; Dworzyński, Jakub; Niedźwiedzka-Rystwej, Paulina; Kopeć, Grzegorz; Grywalska, Ewelina
- Abstract
Pulmonary arterial hypertension (PAH) is a relatively rare disease, but, today, its incidence tends to increase. The severe course of the disease and poor patient survival rate make PAH a major diagnostic and therapeutic challenge. For this reason, a thorough understanding of the pathogenesis of the disease is essential to facilitate the development of more effective therapeutic targets. Research shows that the development of PAH is characterized by a number of abnormalities within the immune system that greatly affect the progression of the disease. In this review, we present key data on the regulated function of immune cells, released cytokines and immunoregulatory molecules in the development of PAH, to help improve diagnosis and targeted immunotherapy.
- Subjects
IMMUNE system; OVERALL survival; DRUG target; SURVIVAL rate; DIAGNOSIS; PULMONARY arterial hypertension
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 16, p3757
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10163757