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- Title
A Cytokine/Bradykinin Storm Comparison: What Is the Relationship Between Hypertension and COVID-19?
- Authors
Wilczynski, Stephanie A; Wenceslau, Camilla F; McCarthy, Cameron G; Webb, R Clinton
- Abstract
The newer bradykinin storm theory stresses the importance of the decreased angiotensin-converting enzyme 2 (ACE2) availability within the epithelial cells of the lungs, leading to an inability to degrade bradykinin analog, des-Arg9-BK within normal margins. However, with decreased levels of SERPINA12 and DPP4 in COVID-19 patients, the kallikrein- kinin system becomes even more active, supplementing the bradykinin storm and triggering the symptoms associated with more severe disease.
- Subjects
COVID-19; BRADYKININ; HYPERTENSION; CYTOKINES; CYTOKINE release syndrome; ANGIOTENSIN converting enzyme
- Publication
American Journal of Hypertension, 2021, Vol 34, Issue 4, p304
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpaa217