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- Title
Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects.
- Authors
Vaou, Natalia; Stavropoulou, Elisavet; Voidarou, Chrysoula; Tsakris, Zacharias; Rozos, Georgios; Tsigalou, Christina; Bezirtzoglou, Eugenia
- Abstract
It is accepted that the medicinal use of complex mixtures of plant-derived bioactive compounds is more effective than purified bioactive compounds due to beneficial combination interactions. However, synergy and antagonism are very difficult to study in a meticulous fashion since most established methods were designed to reduce the complexity of mixtures and identify single bioactive compounds. This study represents a critical review of the current scientific literature on the combined effects of plant-derived extracts/bioactive compounds. A particular emphasis is provided on the identification of antimicrobial synergistic or antagonistic combinations using recent metabolomics methods and elucidation of approaches identifying potential mechanisms that underlie their interactions. Proven examples of synergistic/antagonistic antimicrobial activity of bioactive compounds are also discussed. The focus is also put on the current challenges, difficulties, and problems that need to be overcome and future perspectives surrounding combination effects. The utilization of bioactive compounds from medicinal plant extracts as appropriate antimicrobials is important and needs to be facilitated by means of new metabolomics technologies to discover the most effective combinations among them. Understanding the nature of the interactions between medicinal plant-derived bioactive compounds will result in the development of new combination antimicrobial therapies.
- Subjects
BIOACTIVE compounds; TECHNOLOGICAL innovations; SCIENTIFIC literature; PLANT extracts; TOXICOLOGICAL interactions; CRITICAL currents
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 8, pN.PAG
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11081014