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- Title
Antibiotics and RNase P.
- Authors
Drainas, Denis
- Abstract
RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 51-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA subunit. Its high structural and functional diversity among representatives of a vast variety of phylogenetic domains indicates that RNase P could serve as a molecular target and a useful screening system for the development of new drugs in the battle against bacterial drug resistance.
- Subjects
DRUG development; RIBONUCLEASE P; NUCLEOPROTEINS; ANTIBIOTICS; ENDONUCLEASES; TRANSFER RNA
- Publication
Antibiotics (2079-6382), 2016, Vol 5, Issue 2, p15
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics5020015