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- Title
Contribution of Genetic Factors to Sjögren's Syndrome and Sjögren's Syndrome Related Lymphomagenesis.
- Authors
Nezos, Adrianos; Mavragani, Clio P.
- Abstract
We aimed to summarize the current evidence related to the contributory role of genetic factors in the pathogenesis of Sjögren's syndrome (SS) and SS-related lymphoma. Genes within the major histocompatibility complex (MHC) locus previously considered conferring increased susceptibility to SS development have been also revealed as important contributors in recent genome wide association studies. Moreover, genetic variations outside the MHC locus involving genes in type I interferon pathway, NF-κB signaling, B- and T-cell function and methylation processes have been shown to be associated with both SS and SS-related lymphoma development. Appreciating the functional implications of SS-related genetic variants could provide further insights into our understanding of SS heterogeneity, allowing the design of tailored therapeutic interventions.
- Subjects
SJOGREN'S syndrome; MAJOR histocompatibility complex genetics; CARCINOGENESIS; LYMPHOMAS; DISEASE susceptibility; HETEROGENEITY; BIOLOGICAL variation; NF-kappa B; GENETICS; BIOLOGICAL models; CELLULAR signal transduction; HISTOCOMPATIBILITY antigens; NEOPLASTIC cell transformation; DISEASE complications
- Publication
Journal of Immunology Research, 2015, Vol 2015, p1
- ISSN
2314-8861
- Publication type
journal article
- DOI
10.1155/2015/754825