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- Title
Characterization of an injectable chitosandemineralized bone matrix hybrid for healing critical-size long-bone defects in a rabbit model.
- Authors
SHUANG, F.; HOU, S.-X.; ZHAO, Y.-T.; ZHONG, H.-B.; XUE, C.; ZHU, J.-L.; BU, G.-Y.; CAO, Z.
- Abstract
BACKGROUND: The effect of injectable demineralized bone matrix (DBM) on bone repair is not known. Here, we tested the hypothesis that injectable DBM can heal a criticalsize diaphyseal radius defect in a rabbit model. MATERIALS AND METHODS: The bone defect was filled with DBM powder, injectable DBM or powdered, freeze-dried powdered allografts. Radiological determination, gross evaluation, histology, and micro-computer tomography was carried out 4, 8, and 12 weeks after the surgery, respectively. RESULTS: The injectable DBM group yielded better when compared with the freeze-dried powder group (p < 0.05). Moreover, biomechanical functionality was restored comparable to normal levels in the injectable DBM group. CONCLUSIONS: The injectable DBM was as effective in structurally and functionally repairing bone defects as the DBM powder and more effective than the freeze-dried bone powder. Thus, our study supports the use of injectable DBM for bone healing.
- Subjects
CRYOBIOLOGY; SUBLIMATION (Chemistry); FREEZE-drying; EVAPORATION (Chemistry); HISTOPATHOLOGY
- Publication
European Review for Medical & Pharmacological Sciences, 2014, Vol 18, Issue 5, p740
- ISSN
1128-3602
- Publication type
Article