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- Title
Comparison of inflammatory biomarkers for detection of coronary stenosis in patients with stable coronary artery disease.
- Authors
UYDU, H. A.; BOSTAN, M.; YILMAZ, A.; DEMIR, A.; ATAK, M.; SATIROGLU, Ö.; TEMIZ, A.; CICEK, Y.; ERDOGAN, T.; CETIN, M.; CANGA, A.
- Abstract
BACKGROUND: The objective of the current study was to evaluate the role of various inflammatory biomarkers in detection of coronary stenosis in patients with stable coronary artery disease (CAD) and healthy people. METHODS: A total of 111 patients with stable coronary artery disease, and 66 healthy subjects were enrolled in the study. Serum levels of lipoprotein-associated-phospholipase A2 (Lp-PLA2), high-sensitivity C-reactive protein (hs-CRP), and myeloperoxidase (MPO) were measured to compare patient and control groups. RESULTS: Baseline characteristics were similar between healthy and patient groups, with the exception of age. ANCOVA and log-transformed data of inflammatory biomarkers revealed that, Lp-PLA2 (p < 0,001) and hs-CRP (p < 0,05) levels in all patient groups were significantly higher than in the control group. Conversely, there was no significant difference in MPO levels among groups. CONCLUSIONS: In stable CAD patients, serum Lp-PLA2 levels are more compatible than hs-CRP and MPO levels in the detection of coronary stenosis.
- Publication
European Review for Medical & Pharmacological Sciences, 2013, Vol 17, Issue 1, p112
- ISSN
1128-3602
- Publication type
Article