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- Title
Korrelation zwischen Eingangsparametern und der Performance für ein Miniatur-Fluoreszenzphotometer innerhalb einer Kleinserie.
- Authors
Müller, Ralf; Hintz, Michael; Neckermann, Kristin; Krivanek, Roland; Müller, Achim
- Abstract
This paper deals with the development and the introduction to mass production of a miniaturized fluorescence photometer with two measuring channels (sugar-cube like format). The primary application was implemented in a fibre-based fluorometric dye system for continuous blood glucose measurement. Furthermore, this paper describes the empirical determination of certain tolerances, which could not be determined reliably during the development itself, which was often related to material shortages. The performance of the fluorescence photometers results from the so-called internal cross-talk on the one hand, and from the ratio between the internal cross-talk and the sensitivity as well as from the ratio of the fluorescence signals of measuring channel one and two (relative fluorescence) on the other hand. The input parameters studied were: (1) the scattered light coming from the so-called lighting unit. (2) An optimization parameter determined during the optically active adjustment of the lighting unit. (3) The geometrical offset between the optics of the module and the "coupling aperture" for the multimode optical fibre. No correlation could be demonstrated between (2) and the relative fluorescence. Here, a standard deviation of 0.24 was obtained over 206 modules with a mean value of 6.68 for the relative fluorescence. Regarding (3), no correlation could be established up to a tolerance of ±100 μm for the performance of the modules was found (141 modules). This complies with a low-cost manufacturing.
- Subjects
BLOOD sugar measurement; MASS production; FLUORESCENCE; STANDARD deviations; PHOTOMETERS; BLOOD sugar monitors
- Publication
Technisches Messen, 2023, Vol 90, Issue 4, p237
- ISSN
0171-8096
- Publication type
Article
- DOI
10.1515/teme-2022-0119