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- Title
In Vitro Evaluation of Zinc Oxide Tetrapods as a New Material Component for Glaucoma Implants.
- Authors
Sonntag, Svenja Rebecca; Gniesmer, Stefanie; Gapeeva, Anna; Offermann, Klaus Jakob; Adelung, Rainer; Mishra, Yogendra Kumar; Cojocaru, Ala; Kaps, Sören; Grisanti, Swaantje; Grisanti, Salvatore; Tura, Aysegül
- Abstract
There have been some studies showing the potential success of nanotechnologies in glaucoma surgery [[26]] In our previous study, we were able to show that ZnO tetrapods (ZnO-T), which are new forms of ZnO nanoparticles [[28]], inhibit wound-healing processes, such as fibroblast proliferation, migration, transdifferentiation, and cytokine release [[29]]. A higher level of metabolically active cells could be detected on the implant without the ZnO-nanoparticles (control) compared to the sample with 20% ZnO-T. Arrows indicate the implants that were stabilized at the bottom of the culture wells using silicone rings prior to cell seeding. In detail, the implants of the fine-pored material exhibited a lower level of staining with the MTT dye, compared with the etched samples after the incubation with the HTF cells, suggesting the suppression of cell growth on the surfaces with the ZnO-nanoparticles ( I p i = 0.011, two-sided I t i -test with equal variance, Figure 3A,B). Keywords: glaucoma filtering surgery; nanotechnology; ZnO tetrapods; postoperative encapsulation; antiproliferative substances EN glaucoma filtering surgery nanotechnology ZnO tetrapods postoperative encapsulation antiproliferative substances 1805 12 11/17/22 20221101 NES 221101 1.
- Subjects
GLAUCOMA; TETRAPODS; LASER beam cutting; ZINC oxide; FILTERING surgery; POROUS material testing; OPEN-angle glaucoma
- Publication
Life (2075-1729), 2022, Vol 12, Issue 11, p1805
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life12111805