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- Title
Characteristics of children of the Microcephaly Epidemic Research Group Pediatric Cohort who developed postnatal microcephaly.
- Authors
Ramos, Regina Coeli Ferreira; de Barros Miranda-Filho, Demócrito; Martelli, Celina Maria Turchi; de Araújo, Thália Velho Barreto; Wanderley Rocha, Maria Angela; van der Linden, Vanessa; de Carvalho, Maria Durce Costa Gomes; Rodrigues, Laura Cunha; Montarroyos, Ulisses Ramos; de Souza, Wayner Vieira; de Albuquerque, Maria de Fátima Pessoa Militão; Brickley, Elizabeth B.; de Alencar Ximenes, Ricardo Arraes
- Abstract
The number of studies published on postnatal microcephaly in children with Congenital Zika Syndrome is small, clinical presentations vary and aspects of the evolution of these children remain unclarified. The present case series examined clinical characteristics and assessed the growth velocity of the head circumference, weight and height Z-scores in 23 children who developed postnatal microcephaly during follow-up in the Microcephaly Epidemic Research Group Pediatric Cohort. To estimate the change in the head circumference, weight and height Z-scores over time and compare the mean difference between sexes, we used multilevel mixed-effects linear regressions with child-specific random effects. Among these children, 60.9% (n = 14/23) presented with craniofacial disproportion, 60.9% (n = 14/23) with strabismus, 47.8% (n = 11/23) with early onset seizures, 47.8% (n = 11/23) with dysphagia and 43.5% (n = 10/23) with arthrogryposis. Of the 82.7% (n = 19/23) children who underwent neuroimaging, 78.9% (n = 15/19) presented with alterations in the central nervous system. Monthly growth velocity, expressed in Z-scores, of the head circumference was − 0.098 (95% CI % − 0.117 to − 0.080), of weight was: − 0.010 (95%-CI − 0.033 to 0.014) and of height was: − 0.023 (95%-CI − 0.046 to 0.0001). Postnatal microcephaly occurred mainly in children who had already presented with signs of severe brain damage at birth; there was variability in weight and height development, with no set pattern.
- Subjects
ZIKA virus infections; MICROCEPHALY; RESEARCH teams; CENTRAL nervous system; SYMPTOMS
- Publication
Scientific Reports, 2022, Vol 12, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-022-19389-w