We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps.
- Authors
De Corso, Eugenio; Baroni, Silvia; Settimi, Stefano; Onori, Maria Elisabetta; Mastrapasqua, Rodolfo Francesco; Troiani, Eliana; Moretti, Giacomo; Lucchetti, Donatella; Corbò, Marco; Montuori, Claudio; Cantiani, Alessandro; Porru, Davide Paolo; Lo Verde, Simone; Di Bella, Giuseppe Alberto; Caruso, Cristiano; Galli, Jacopo
- Abstract
The complex pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) generates a spectrum of phenotypes with a wide variety of inflammatory states. We enrolled 44 very-likely-to-be type 2 CRSwNP patients in order to evaluate the load of inflammation and to analyze human interleukins in nasal secretion. Clinical data were collected to evaluate the severity of the disease. High levels of IL-5, IL-4, IL-6, and IL-33 were detected in all type 2 CRSwNP patients. By analyzing type 2 cytokine profiles and local eosinophil count, we identified two coherent clusters: the first was characterized by high levels of IL-4, IL-5, IL-6, and a high-grade eosinophil count (type 2-high); the second had lower levels of cytokines and poor or absent eosinophilic inflammation (type-2 low). IL-5 levels were significantly higher within the type 2 cytokine and it was the most reliable biomarker for differentiating the two clusters. In type 2-high inflammatory profile clinical scores, the mean number of previous surgeries and need for systemic corticosteroids were significantly higher compared to type 2-low. Our research demonstrated the potential role of type 2 biomarkers, and in particular, of IL-5 in identifying patients with a more severe phenotype based on a high inflammatory load.
- Subjects
NASAL polyps; SINUSITIS; INFLAMMATION; PARANASAL sinuses; BIOMARKERS; ADENOMATOUS polyps; EOSINOPHILIA
- Publication
Journal of Personalized Medicine, 2022, Vol 12, Issue 8, p1251
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm12081251