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- Title
Zic2 is required for enteric nervous system development and neurite outgrowth: a mouse model of enteric hyperplasia and dysplasia.
- Authors
Zhang, Y.; Niswander, L.
- Abstract
From a forward genetic screen in mice we isolated a novel Zic2 allele with abnormal aggregation of meconium in the gastrointestinal tract. Zic2m1Nisw mutant embryos show an increase in the number of enteric neurons in vivo and disorganization of the neurite network. Explant culture of Zic2m1Nisw gastrointestinal tract show extensive neurite outgrowth, suggesting that Zic2 is a negative regulator of nerve fiber growth. These studies demonstrate a previously unknown function of Zic2 and provide a novel animal model of enteric nervous system dysplasia and hyperplasia.
- Subjects
NOGO protein; DYSPLASIA; RETICULON proteins; ENZYME inhibitors; HYPERPLASIA
- Publication
Neurogastroenterology & Motility, 2013, Vol 25, Issue 6, p538
- ISSN
1350-1925
- Publication type
Article
- DOI
10.1111/nmo.12101