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- Title
Isotype distribution of mucosal IgG-producing cells in patients with various IgG subclass deficiencies.
- Authors
Nilssen, D. E.; Söderström, R.; Brandtzaeg, P.; Kett, K.; Helgeland, L.; Karlsson, G.; T. Söderström; Hånson, L. A.
- Abstract
The subclass distribution or IgG-producing immunocytes was examined by immunohistochemistry in nasal and rectal mucosa of infection-prone patients with untreated IgG subclass deficiencies. Biopsy specimens from the two sites were obtained in 18 clinically and serologically well-characterized adult subjects; only a nasal or rectal sample was available from nine similar patients. Chronic lung disease was common in the patient groups with selective serum IgG1 deficiency and combined IgG1 and IgG3 deficiency, whereas the other categories of patients had mainly upper airway and other mild infections. Scrum IgG2 or IgG3 deficiency was usually expressed also at the cellular level in rectal mucosa, and the proportion of rectal IgG1 cells was significantly correlated with the IgG1 level (r = 0.90, P < 0.001) . Likewise, there tended to be a decreased expression of the actual subclass at the cellular level in nasal mucosa of patients with scrum IgG1 or IgG2 deficiency. Conversely, the median nasal proportion of IgG3 cells was remarkably unaffected by a deficiency of this subclass in serum and rectal mucosa. Interestingly, these patients rather [ended to have raised IgG3 and reduced IgG2 cell proportions in their nasal mucosa. although this apparent local IgG3 compensation was nevertheless strongly correlated with the serum IgG3 level (r = 0.87, P < 0.002). These disparities may reflect different antigenic and mitogenic exposure of the two tissue sites; for example, a persistent protein bombardment of the nasal mucosa that could conceivably override locally a B cell maturation defect. The possible clinical consequences of such variable mucosal expression of IgG subclass deficiencies remain to be studied.
- Subjects
IMMUNOCHEMISTRY; IMMUNITY; BIOPSY; LUNG diseases; SERUM; B cells
- Publication
Clinical & Experimental Immunology, 1991, Vol 83, Issue 1, p17
- ISSN
0009-9104
- Publication type
Article