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- Title
Leishmania mexicana amazonensis infections in 'resistant' inbred mice following removal of the draining lymph node.
- Authors
Reed, S. G.; Andrade, Z. A.; Roters, Silene B.; Inverso, Jill A.; Sadigursky, M.
- Abstract
Highly resistant (C57BL/10) and intermediately resistant (DBA/2) mice were infected subcutaneously with Leishmania mexicana amazonensis in a hind footpad subsequent to removal of the draining popliteal node. These mice developed greatly exacerbated Leishmatania infections as compared lo sham-operated controls or to mice infected in the contralateral footpad. The majority of mice in which the draining lymph nodes were removed prior to infection developed metastases, lost their delayed hypersensitivity responses to Leishmania, and some died, Significantly fewer metastases and no deaths were observed in the control groups. The results emphasize the importance of lymphatic control of Leishmania m. amazonensis infection in relatively resistant mouse strains.
- Subjects
LEISHMANIA; INFECTION; PATHOLOGY; BODY fluids; LYMPH nodes; CELLULAR immunity; MICE
- Publication
Clinical & Experimental Immunology, 1986, Vol 64, Issue 1, p8
- ISSN
0009-9104
- Publication type
Article