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- Title
Influence of Interleukin-10 Gene G-1082A Polymorphism on the Progression of Primary Glomerulonephritis.
- Authors
Bantis, C.; Heering, P.; Aker, S.; Klein-Vehne, N.; Grabensee, B.; Ivens, K.
- Abstract
Objective: Interleukin-10 (IL-10) is a cytokine with immuno-suppressive properties. We evaluated the influence of G-1082A polymorphism in the IL-10 gene promoter, which has been associated with modified IL-10 production, on the clinical course of chronic glomerulonephritis. Methods: We studied n = 251 patients with biopsy proven primary chronic glomerulonephritis (IgA nephropathy: n = 127, focal segmental glomerulosclerosis: n = 71, membranous glomerulonephritis: n = 53) followed up for 6.2 ± 5.3 years. According to the slope of the curve of reciprocal serum creatinine against time (≥or< - 0.1 dl X mg-1 X year-1) group A (slow progressors, n = 162) and group B (fast progressors, n = 89) were defined. One hundred volunteers were analysed as controls. IL-10 gene G-1082A polymorphism was determined by PCR amplification. Results: The genotype frequencies were similar in patients and control subjects (ns). Age, initial renal function, proteinuria and blood pressure did not differ significantly between patients with different genotypes. G-1082A polymorphism influenced the rate progression, with the IL-10 low producer genotype (carriage of the a-allele, GA and AA genotypes) being associated with a worse prognosis. The low producer genotype was significantly over represented in group B (fast progressors: 88.8%) than in group A (slow progressors: 70.4%; p > 0.001). In the Kaplan Meier analysis of kidney survival patients with the low producing genotype showed a significantly worse outcome (7.2 ± 0.7 years) compared to high producers (12.8 ± 2.3 years, mean ± SE, p = 0.002). The IL-10 genotype remained an independent risk factor for progression in multivariate analysis (Cox regression model: HR for the IL-10 low producing genotype: 1.46, 95.0% CI: 1.15 to 1.84, p = 0.001). Conclusions: Our results suggest that IL-10 gene G-1082A polymorphism is an important marker of progression in patients with primary glomerulonephritis.
- Subjects
INTERLEUKIN-10; GENETIC polymorphisms; GLOMERULONEPHRITIS; IGA glomerulonephritis; CREATININE; KIDNEY diseases
- Publication
Kidney & Blood Pressure Research, 2004, Vol 27, Issue 5/6, p288
- ISSN
1420-4096
- Publication type
Article