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- Title
Role of fibroblast-derived factors in the pathogenesis of melasma.
- Authors
Byun, J. W.; Park, I. S.; Choi, G. S.; Shin, J.
- Abstract
Background The hyperactive melanocytes present in melasma skin are confined to the epidermis, but epidermal ablation to treat melasma pigmentation may lead to disease recurrence and aggravation. Melanocyte function is regulated by interactions between melanocytes and neighbouring cells such as keratinocytes and fibroblasts. Because melasma skin usually shows dermal changes after exposure to sunlight, we hypothesized that sun-damaged fibroblasts might play a crucial role in the pathogenesis of melasma. Aim In this study, the melanogenic role of primary cultured fibroblasts from human melasma skin was investigated. Methods We explored whether primary cultured fibroblasts from melasma tissue have a melanogenic function on cultured human epidermal melanocytes and artificial skin. The cytokine profile derived from fibroblasts and their effect on the pigmented epidermal equivalents were investigated. Results Fibroblasts from the melasma lesion and perilesional skin increased melanogenesis in cultured human epidermal melanocytes and in artificial skin. Fibroblasts from the melasma lesion and perilesional skin secreted more nerve growth factor ( NGF)-β than those in normal buttock skin, and also increased melanogenesis and the expression level of NGF-β in cultured human epidermal melanocytes and artificial skin. Conclusions These results suggest that fibroblasts may play a role in melanogenesis and the pathogenesis of melasma.
- Subjects
MELANOSIS; FIBROBLASTS; DESMOID tumors; PIGMENTATION disorders; MELANOCYTES
- Publication
Clinical & Experimental Dermatology, 2016, Vol 41, Issue 6, p601
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/ced.12874