We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
NEUROINFLAMMATORY EFFECTS OF TDCS IN OVARIECTOMIZED RATS WITH CHRONIC INFLAMMATION.
- Authors
Torres, Iraci L. S.; de Oliveira, Carla; Leal Scarabelot, Vanessa; Vercelino, Rafael; de Souza, Andressa; Silva Moreira, Sônia Fátima; Visioli, Fernanda; Caumo, Wolnei; Fernandes Medeiros, Liciane
- Abstract
Introduction: Postmenopausal women are more susceptible to chronic conditions, such as osteoporosis, arthritis, and other inflammatory diseases. We investigated the effects of transcranial direct current stimulation (tDCS) on biomarker levels in ovariectomized rats subjected to an inflammatory model. Methods: Twenty adult female Wistar rats underwent ovariectomy and complete Freund's adjuvant (CFA)-induced inflammation. We divided them into 2 groups: OAS (sham tDCS) and OAT (active tDCS). Fifteen days later, the rats underwent bimodal tDCS treatment (20 min, 0.5 mA, 8 days). After 24 h of the last tDCS session, we killed the rats and collected tissue samples (hypothalamus, cerebral cortex, and brainstem) for biomarker analysis by ELISA. We removed the paws for histological analysis. Results: Active tDCS increased hypothalamic and cortical TNF-a and NGF levels, hypothalamic and brainstem IL-1ß levels, and hypothalamic IL-10 levels. Histology of paws showed an inflammatory profile. We observed a small tDCS effect, not statistically significant. Discussion: Bimodal tDCS had an effect on the central inflammatory axis, with a small effect on the peripheral site as evaluated by histology in the current study.
- Subjects
ORGANIZATION of American States; TRANSCRANIAL direct current stimulation; CEREBRAL cortex; LABORATORY rats; INFLAMMATION; RATS
- Publication
Clinical & Biomedical Research, 2021, Vol 41, Issue 4, p332
- ISSN
2357-9730
- Publication type
Article
- DOI
10.22491/2357-9730.113072