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- Title
Effects of decongestant addition to intranasal corticosteroid for chronic rhinitis: a systematic review and meta‐analysis.
- Authors
Khattiyawittayakun, Likhit; Seresirikachorn, Kachorn; Chitsuthipakorn, Wirach; Kanjanawasee, Dichapong; Snidvongs, Kornkiat
- Abstract
Background: Intranasal corticosteroid (INCS) is the most efficacious medicine for treating chronic rhinitis. A decongestant and INCS combination (INCS‐D) is considered for nasal congestion that is not improved by INCS. This study aimed to investigate the effects of INCS‐D on chronic rhinitis. Methods: Literature searches were performed using MEDLINE and EMBASE. Randomized controlled trials studying the effects of INCS‐D vs INCS alone for treating chronic rhinitis were included. Data were pooled for meta‐analysis. Outcomes were nasal symptoms, disease‐specific quality of life, objective tests for nasal patency, and adverse events. Results: Six studies (1071 patients) met the inclusion criteria. There were no differences between INCS‐D and INCS on total nasal symptom scores (standardized mean difference [SMD] −0.85; 95% confidence interval [CI], −2.09 to 0.40; p = 0.18), nasal congestion scores (SMD −0.13; 95% CI, −0.46 to 0.20; p = 0.43), and the Rhinoconjunctivitis Quality of Life Questionnaire score (SMD −0.12; 95% CI, −0.66 to 0.42; p = 0.66). After 1 week, there were no differences on objective tests for nasal patency (acoustic rhinometry: SMD 0.04; 95% CI, −0.68 to 0.76, p = 0.91; and peak nasal inspiratory flow: SMD 0.08; 95% CI, −0.16 to 0.32; p = 0.52). Adverse events were not different between INCS‐D and INCS (risk ratio 1.09; 95% CI, 0.73 to 1.62). Conclusion: Meta‐analyses did not show benefits of topical decongestants addition to INCS. Adverse events of INCS‐D were comparable with INCS.
- Subjects
CORTICOSTEROIDS; RHINITIS treatment; DRUG efficacy; CHRONIC disease treatment; META-analysis
- Publication
International Forum of Allergy & Rhinology, 2018, Vol 8, Issue 12, p1445
- ISSN
2042-6976
- Publication type
Article
- DOI
10.1002/alr.22193