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- Title
Ameliorative effect of 'Zingiber offinale and Allium sativum' on the hippocampus of streptozotocin induced diabetes mellitus in adult male wistar rat models.
- Authors
Taiwo Ola, Dorcas Olubunmi; Fakunle, Ponle Bamidele; Otulana, Olatoye Jubril; Odubela, Olukayode Olusola; Koku, Adenike Boluwatife; Oyejide, Praise Olamide; Ifarajimi, Raphael Olabode
- Abstract
Objective: Diabetes mellitus is an endocrine disease that leads to functional and structural changes in the brain. It often leads to a number of complications, including cognitive decline and depression. The aim is to study the effects of Zingiber officinale and Allium sativum on the hippocampus of streptozotocin induced diabetes mellitus in adult male wistar rats. Methods: 36 rats were allocated into nine (9) groups: control group (NC), diabetic control (DC), standard drug, diabetes+ ethanol Ginger and Garlic 400 mg/kg, diabetes + aqueous Ginger and garlic 400 mg/kg, diabetic + Ginger 300 mg/kg, diabetic + garlic 300 mg/kg, and Ethanol Ginger + Garlic 400 mg/kg and aqueous Ginger+ Garlic 400 mg/kg were given orally for 14 days, following diabetes mellitus induction of multiple dose of STZ (70 kg/kg body weight) intraperitoneally. For spatial memory and learning, neurobehavioural assay and histological stain of the hippocampi was done. Results: The hippocampus of the normal control group showed the granular cell layer (GL) and normal pyramidal cells (PC). Diabetic control showed a section of granule cell layer of the dentate gyrus, there was presence of vacuolation and pale nuclei. The group treated with Metformin showed mild distortion of the granular cell layer, darkening of the cells and presence of pale nuclei. Treatment with extracts showed its effect in restoration of neuronal cells with distinctive characteristic cell layers in ethanolic extracts of Z. offinale and A. sativum mix over the aqueous extract mixture. Conclusion: This study has shown a relationship between the two extracts and how significant they can be to the hippocampus of a diabetic adult wistar rat.
- Subjects
ANIMAL models of diabetes; LABORATORY rats; DIABETES; GINGER; GARLIC; ZINGIBER; HIPPOCAMPUS (Brain); METFORMIN; ETHANOL
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2022, Vol 16, pS131
- ISSN
1307-8798
- Publication type
Abstract