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- Title
Oligoclonal IgG and Free Light Chains in the Cerebrospinal Fluid of Patients with Multiple Sclerosis and Infectious Diseases of the Central Nervous System.
- Authors
Vandvik, B.
- Abstract
Conventional and crossed immunoelectrophoresis were used to characterize oligoclonal γ-globulin bands of the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) or subacute sclerosing panencephalitis (SSPE) or other infections of the central nervous system. Most γ-globulin bands were identified as IgG, but some bands were identified as K or &lamda; or both, free light chains. Bands of IgG showed various degrees of light-chain diversity, and individual bands appeared in many instances to be derived from more than one clone of cells. Sequential changes of the oligoclonal IgG were observed in SSPE but not in MS. Oligoclonal IgG was detected in sera from most patients with SSPE and some patients with MS.
- Subjects
IMMUNOELECTROPHORESIS; NERVOUS system; CEREBROSPINAL fluid; IMMUNODIAGNOSIS; PATIENTS; IMMUNOGLOBULIN G
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 9, p913
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb00412.x