We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Constraint of Base Pairing on HDV Genome Evolution.
- Authors
Nagata, Saki; Kiyohara, Ryoji; Toh, Hiroyuki
- Abstract
The hepatitis delta virus is a single-stranded circular RNA virus, which is characterized by high self-complementarity. About 70% of the genome sequences can form base-pairs with internal nucleotides. There are many studies on the evolution of the hepatitis delta virus. However, the secondary structure has not been taken into account in these studies. In this study, we developed a method to examine the effect of base pairing as a constraint on the nucleotide substitutions during the evolution of the hepatitis delta virus. The method revealed that the base pairing can reduce the evolutionary rate in the non-coding region of the virus. In addition, it is suggested that the non-coding nucleotides without base pairing may be under some constraint, and that the intensity of the constraint is weaker than that by the base pairing but stronger than that on the synonymous site.
- Subjects
BASE pairs; HEPATITIS D virus; CIRCULAR RNA; RNA viruses; NUCLEOTIDES
- Publication
Viruses (1999-4915), 2021, Vol 13, Issue 12, p2350
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v13122350