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- Title
Effects of vitamin D deficient diet on microtubule-associated protein 2 expression in brains of newborn mice.
- Authors
Jiawen Huo; Hongyun Shi; Qingpeng Hu; Yuanlu Huang; Wei Feng
- Abstract
Functioning as a neuroactive steroid hormone, vitamin D assumes a pivotal role in brain development, function and dynamic equilibrium. Inadequate vitamin D levels can lead to diminished expression of genes related to the growth and apoptosis of mouse brain cells. This deficiency extends to the next generation. Microtubule-associated protein 2 (MAP2), closely linked to neural cell differentiation and migration, acts as a neural cell-specific marker. It is expressed in both the neuronal cytoplasm and dendrites, serving as a substrate for the majority of protein kinases and phosphatases found in neurons. Our study findings unveil a reduction in MAP2 expression in the brains of newborn mice from pregnant mice with a diet deficient in vitamin D. Vitamin D deficiency status thus serves as a potential molecular indicator for diagnosing and prognosticating mental developmental disorders, opening avenues for novel therapeutic strategies.
- Subjects
MICROTUBULE-associated proteins; VITAMIN D; MALNUTRITION; DIETARY proteins; PROTEIN expression
- Publication
Maejo International Journal of Science & Technology, 2024, Vol 18, Issue 1, p115
- ISSN
1905-7873
- Publication type
Article