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- Title
The activation of NLRP3 inflammasome in tissue-resident macrophages contributes to enteric neuroplastic remodelling in a mouse model of diet-induced obesity.
- Authors
Pellegrini, Carolina; Benvenuti, Laura; D'Antongiovanni, Vanessa; Segnani, Cristina; Ippolito, Chiara; Nericcio, Anna; Lopez-Castejon, Gloria; Pelegrin, Pablo; Bernardini, Nunzia
- Abstract
The article discusses a study conducted to examine mucosal permeability, immune/inflammatory responses and colonic motility in mice with high-fat diet (HFD)-induced obesity. In the setting of obesity, the activation of NLRP3 inflammasome in tissue-resident macrophages contributes to colonic dysmotility, through the modulation of tachykininergic neurogenic responses, thus identifying NLRP3 as a therapeutic target for the treatment of bowel symptoms related to obesity.
- Subjects
NLRP3 protein; INFLAMMASOMES; LABORATORY mice; ANIMAL disease models; MACROPHAGES
- Publication
Italian Journal of Anatomy & Embryology / Archivio Italiano di Anatomia Ed Embriologia, 2021, Vol 125, p99
- ISSN
1122-6714
- Publication type
Article