We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines under Solvent‐Free Conditions.
- Authors
Zuo, Wanqing; Zhu, Zhizhen; Cheng, Yu; Zuo, Lingling; Geng, Xiao; Li, Zhifang; Wang, Lei
- Abstract
Comprehensive Summary: The development of switchable solvent‐free multicomponent reactions to build high‐value‐added products is an important demand for organic synthesis. Herein, we detailed the successful implementation of a switchable strategy for the construction of diverse 4‐fluoroalkyl‐1,4‐dihydropyrimidines and 4‐fluoroalkyl‐pyrimidines via a solvent/additive‐free [3 + 2 + 1] annulation, starting from readily available enamines, trifluoroacetaldehyde hydrate or 1‐ethoxy‐2,2‐difluoroethanol and amidines hydrochloride. This reaction conforms to the concept of green synthesis, and provides a new avenue to access valuable fluorinated heterocycles.
- Subjects
RING formation (Chemistry); ORGANIC synthesis; AMIDINES; ENVIRONMENTAL chemistry; ANNULATION; ENAMINES
- Publication
Chinese Journal of Chemistry, 2024, Vol 42, Issue 12, p1394
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202300725