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- Title
Evaluation of Antidepressant and Anxiolytic Activity of Phosphodiesterase 3 Inhibitor - Cilostazol.
- Authors
Patel, Dipesh S.; Anand, Indermeet Singh; Bhatt, Parloop A.
- Abstract
Background: Cyclic nucleotide Phosphodiesterases (PDEs) are ubiquitously distributed in mammalian tissues and play a major role in cell signaling by hydrolyzing cyclic Adenosine Monophosphate (cAMP) and cyclic Guanosine Monophosphate (cGMP). Impairments in signal transduction have been implicated as possible mechanism of reduced plasticity and neuronal survival in major depressive disorders. PDE inhibitors possess a potentially powerful means to manipulate secondary messengers involved in learning, memory and mood. Cilostazol is an antiplatelet agent indicated for the treatment of intermittent claudication with peripheral artery occlusion and for the prevention of ischemic stroke worldwide. Various animal studies have reported neuroprotective, anti apoptotic, cognition and cerebral blood flow improvement properties of cilostazol. Materials and Methods: In this study, the antidepressant and anxiolytic effects of cilostazol were evaluated in mice using behavioral tests sensitive to clinically effective antidepressant compound. Results: Cilostazol, administered intraperitoneally (20 mg/kg), decreased immobility time of mice when subjected to forced swim test and tail suspension test as compared to standard fluoxetine (20 mg/kg). Cilostazol also produced significant decrease in the number of marbles buried as compared to fluoxetine in marble burying model. Conclusion: The present study suggests that cilostazol possesses potential antidepressant and anxiolytic activity, which could be of therapeutic interest for use in patients with depressive disorders.
- Subjects
ANTIDEPRESSANTS; CYCLIC nucleotide phosphodiesterases; PHOSPHODIESTERASE inhibitors; TRANQUILIZING drugs; ADENOSINE monophosphate; GUANOSINE monophosphate phosphodiesterase; CEREBRAL circulation
- Publication
Indian Journal of Psychological Medicine, 2012, Vol 34, Issue 2, p124
- ISSN
0253-7176
- Publication type
Article
- DOI
10.4103/0253-7176.101776