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- Title
Isolation and Characterization of Glycosidic Tyrosinase Inhibitors from Typhonium giganteum Rhizomes.
- Authors
Penghua Shu; Huiqing Zhu; Wanrong Liu; Lingxiang Zhang; Junping Li; Mengzhu Yu; Yingying Fei; Shujing Cai; Ruihua Li; Xialan Wei; Wenhan Yi; Fugang Xiao
- Abstract
A new hydrocinnamoyl glucoside, 1-O-(4-hydroxyhydrocinnamoyl)-β-D-glucopyranose (1), together with fifteen known glycosides, including two phenylethanoid glycosides (2--3), two cinnamoyl glycosides (4-5), six phenolic glycosides (6-11), one lignan glycoside (12) and four megastigmane glycosides (13-16) were isolated from a 95% EtOH extract of the Typhonium giganteum rhizomes. The sixteen glycosides were structurally characterized by NMR, HRESIMS, enzymatic hydrolysis and comparison with literature. Upon evaluating inhibitory activities of compounds 1-16 against mushroom tyrosinase at 25 µM, compounds 10 and 11 exhibited obvious inhibitory activities, with %inhibition values of 20.94±0.59%, 23.28±1.09%, respectively, with arbutin used as the positive control (26.21±0.58%).
- Subjects
PHENOL oxidase; GLYCOSIDES; HYDROLYSIS; MUSHROOMS
- Publication
Records of Natural Products, 2021, Vol 15, Issue 5, p380
- ISSN
1307-6167
- Publication type
Article
- DOI
10.25135/rnp.230.21.02.1965